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Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity is increased, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Methaqualone peaks in the bloodstream within several hours, with a half-life of 20–60 hours. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma, and death. Methaqualone is not recommended for use while pregnant or during pregnancy.

Uses of Quaaludes

In prescribed doses, Quaaludes promotes relaxation, sleepiness, and sometimes a feeling of euphoria. It causes a drop in blood pressure and slows the pulse rate. These properties are the reason why it was initially thought to be a useful sedative and anxiolytic.

Contraindications for Quaaludes

Quaaludes should not be taken with alcohol or with other central nervous system depressants. This increases the depressant effects, and depending on the doses taken, it can be fatal.
Do not drive or operate machinery while taking Quaaludes.
Quaaludes are not recommended during pregnancy as the effects on human fetal development are not clear.

Side effects of Quaaludes

Dizziness, nausea, vomiting, diarrhea, abdominal cramps, fatigue, itching, tingling sensation in arms and legs, seizures
Note that the depressant effects of Quaaludes may include reduced heart rate and respiration.

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